Literature-based condition-specific miRNA-mRNA target prediction
نویسندگان
چکیده
منابع مشابه
Literature-based condition-specific miRNA-mRNA target prediction
miRNAs are small non-coding RNAs that regulate gene expression by binding to the 3'-UTR of genes. Many recent studies have reported that miRNAs play important biological roles by regulating specific mRNAs or genes. Many sequence-based target prediction algorithms have been developed to predict miRNA targets. However, these methods are not designed for condition-specific target predictions and p...
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Recently, a class of small RNA molecules, microRNAs or miRNAs, has attracted interest from researchers for their unique role in post-transcriptional regulation. Due to their distinct cell-type/tissue-specific expression patterns, it is of high importance to identify conditionspecific miRNA-gene modules for a complete depiction of gene regulatory networks. In this paper, we propose a novel metho...
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MOTIVATION MicroRNAs (miRNAs) play crucial roles in complex cellular networks by binding to the messenger RNAs (mRNAs) of protein coding genes. It has been found that miRNA regulation is often condition-specific. A number of computational approaches have been developed to identify miRNA activity specific to a condition of interest using gene expression data. However, most of the methods only us...
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MicroRNAs (miRNAs) suppress gene expression by forming a duplex with a target messenger RNA (mRNA), blocking translation or initiating cleavage. Computational approaches have proven valuable for predicting which mRNAs can be targeted by a given miRNA, but currently available prediction methods do not address the extent of duplex formation under physiological conditions. Some miRNAs can at low c...
متن کاملCondition-specific target prediction from motifs and expression
MOTIVATION It is commonplace to predict targets of transcription factors (TFs) by sequence matching with their binding motifs. However, this ignores the particular condition of the cells. Gene expression data can provide condition-specific information, as is, e.g. exploited in Motif Enrichment Analysis. RESULTS Here, we introduce a novel tool named condition-specific target prediction (CSTP) ...
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ژورنال
عنوان ژورنال: PLOS ONE
سال: 2017
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0174999